Green Tea for Keloids

New research from Korea shows that EGCG selectively suppressed
keloid fibroblast proliferation and migration compared to its effect on
normal fibroblast proliferation and migration. Keloids are common
benign skin tumors, characterized by collagen accumulation and
hyperproliferation of fibroblasts.

Green Tea Polyphenol Epigallocatechin-3-Gallate Suppresses Collagen
Production and Proliferation in Keloid Fibroblasts via Inhibition of
the STAT3-Signaling Pathway.

J Invest Dermatol. 2008 May 8. Park G, Yoon BS, Moon JH, Kim B, Jun EK, Oh S, Kim H, Song HJ, Noh JY, Oh C, You S.

Keloids are benign skin tumors characterized by collagen
accumulation and hyperproliferation of fibroblasts. To find an
effective therapy for keloids, we explored the pharmacological
potential of (-)-epigallocatechin-3-gallate (EGCG), a widely
investigated tumor-preventive agent. When applied to normal and keloid
fibroblasts (KFs) in vitro, proliferation and migration of KFs were
more strongly suppressed by EGCG than normal fibroblast proliferation
and migration (IC(50): 54.4 muM (keloid fibroblast (KF)) versus 63.0
muM (NF)). The level of Smad2/3, signal transducer and activator of
transcription-3 (STAT3), and p38 phosphorylation is more enhanced in
KFs, and EGCG inhibited phosphorylation of
phosphatidylinositol-3-kinase (PI3K), extracellular signal-regulated
protein kinase 1/2 (ERK1/2), and STAT3 (Tyr705 and Ser727). To evaluate
the contribution of these pathways to keloid pathology, we treated KFs
with specific inhibitors for PI3K, ERK1/2, or STAT3. Although a PI3K
inhibitor significantly suppressed proliferation, PI3K and MEK/ERK
inhibitors had a minor effect on migration and collagen production.
However, a JAK2/STAT3 inhibitor and a STAT3 siRNA strongly suppressed
proliferation, migration, and collagen production by KFs. We also found
that treatment with EGCG suppressed growth and collagen production in
the in vivo keloid model. This study demonstrates that EGCG suppresses
the pathological characteristics of keloids through inhibition of the
STAT3-signaling pathway. We propose that EGCG has potential in the
treatment and prevention of keloids.Journal of Investigative
Dermatology advance online publication, 8 May 2008;

No comments yet.

Leave a Reply