Green Tea Polyphenols (GTP) Against Skin Cancer

February 24, 2009 by  
Filed under All, Science

In studies conducted on human skin, green tea polyphenols prevented ultraviolet (UVB) induced chemical changes in the skin, which are considered to be mediators of UVB induced immunosuppression and skin cancer induction. GTP treated humans can prevented penetration of UV radiation, and protected against UVB-induced local as well as systemic immune suppression in laboratory animals. “These in vivo observations suggest that GTP is our photo protective and can be used as pharmacological agents for the prevention of solar UVB light induced skin disorders associated with immune suppression and DNA damage.”

Alternative Medicine Review April 1, 2002 Bergamo, BM; Elmets, CA; Katiyar, SK; Vyalil, PK

Green tea polyphenols: DNA photodamage and photoimmunology.(Abstract)

atiyar SK, Bergamo BM, Vyalil PK, Elmets CA. J Photochem Photobiol B 2001;6:109-114.

Green tea is a popular beverage consumed worldwide. The epicatechin derivatives, which are commonly called `polyphenols’, are the active ingredients in green tea and possess antioxidant, anti-inflammatory and anti-carcinogenic properties. Studies conducted by our group on human skin have demonstrated that green tea polyphenols (GTP) prevent ultraviolet (UV)-B-induced cyclobutane pyrimidine dimers (CPD), which are considered to be mediators of UVB-induced immune suppression and skin cancer induction. GTP treated human skin prevented penetration of UV radiation, which was demonstrated by the absence of immunostaining for CPD in the reticular dermis. The topical application of GTP or its most potent chemopreventive constituent (-)-epigallocatechin-3-gallate (EGCG) prior to exposure to UVB protects against UVB-induced local as well as systemic immune suppression in laboratory animals. Additionally, studies have shown that EGCG treatment of mouse skin inhibits UVB-induced infiltration of CD11b+ cells. CD11b is a cell surface marker for activated macrophages and neutrophils, which are associated with induction of UVB-induced suppression of contact hypersensitivity responses. EGCG treatment also results in reduction of the UVB-induced immunoregulatory cytokine interleukin (IL)-10 in skin as well as in draining lymph nodes, and an elevated amount of IL-12 in draining lymph nodes. These in vivo observations suggest that GTPs are photoprotective, and can be used as pharmacological agents for the prevention of solar UVB light-induced skin disorders associated with immune suppression and DNA damage.

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