Research in stroke-prone spontaneously hypertensive rats demonstrated benefits from both black and green tea polyphenols. Oxidative stress is reportedly involved not only in cardiovascular disease but also in hypertension. Using continuous monitoring of blood pressure, both green tea polyphenols and black tea polyphenols significantly reduced both systolic and diastolic blood pressure compared with controls. “These data demonstrate that both black and green tea polyphenols attenuate blood pressure increases through their antioxidant properties. Furthermore, because the amounts of polyphenols used in this experiment correspond to those in 1 liter of tea, the regular consumption of black and green tea may also provide some protection against hypertension in humans.” Read more
Green Tea Polyphenol Administration Partly Ameliorates Chemotherapy-Induced Side Effects in the Small Intestine of Mice
The chemotherapy agent irinotecan is highly effective against several types of cancer, but its use is limited due to severe intestinal toxicity. Green tea polyphenols (1 g per liter) used for seven days before and three days after treatment reduced the toxicity. “Green tea polyphenols supplied orally protected against oxidation in our experimental model and could be one approach to reducing the risk of chemotherapy induced side effects in a clinical setting.”
Rationale: The intermittent hypoxia (IH) that characterizes sleep disordered breathing impairs spatial learning and increases NADPH oxidase activity and oxidative stress in rodents. We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IHinduced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation.
Conclusions: Oral GTP attenuates IH-induced spatial learning deficits and mitigates IH-induced oxidative stress through multiple beneficial effects on oxidant pathways. Because oxidative processes underlie neurocognitive deficits associated with IH, the potential therapeutic role of GTP in sleep-disordered breathing deserves further exploration.