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Flaxseed (Linum usitatissimum) Supplementation reduces metastasis of melanoma cells in mice

  Consumption of a diet rich in whole grains, fruits and vegetables has been associated with the reduction of risk of certain cancers. One possible contribution to this benefit may come from lignans, diphenolic compounds present in foods of plant origin. These compounds possess estrogenic, antiestrogenic, antiproliferative and antioxidative properties. Flaxseed, a substance rich in lignan precursor SDG, has been used experimentally as a dietary source of lignans to investigate the possible role of these compounds in cancer prevention. Inhibition of carcinogenesis and tumorigenesis by flaxseed has been observed previously. The present study investigated the effect of dietary flaxseed supplementation on experimental metastasis of intravenously injected melanoma cells in mice. Supplementation resulted in decreased number, area and volume of lung tumors. Flaxseed therefore appears to reduce the pulmonary metastasis of melanoma cells and inhibit tumor growth. Based on these findings, the researchers concluded that flaxseed products may be useful adjunctive therapies to prevent metastasis.  
  Yan L, Yee J, Li D, et al. "Dietary flaxseed supplementation and experimental metastasis of melanoma cells in mice." Cancer Letters 1998;124:181-186.  
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