||Patients with precancerous
oral lesions (for example, oral submucous fibrosis) show increased numbers
of micronuclei (Mn) in exfoliated oral mucosal cells and circulating lymphocytes.
Administration of an alcoholic turmeric extract to oral submucous fibrosis
patients relieved their symptoms and lowered the incidence of Mn relative
to that of healthy subjects. This study, which included both in vivo
and in vitro experiments, investigated the decreased incidence
of Mn in oral mucosal cells and circulating lymphocytes when treated by
turmeric oil (TO), turmeric oleoresin (TOR) and turmeric extract (TE).
Both TO and TOR gave significant protection against chemically induced
increased Mn in vitro, similar to TE (previous study). In vivo
studies showed TOR to be significantly more effective in reducing the
number of Mn compared to TO and TE. Both TO and TOR act systemically on
target cells such as oral mucosal cells, conferring chemoprotective activity
against chemically induced DNA damage in vitro. Hastak K, Lubri N, Jakhi
S, et al. Effect of turmeric oil and turmeric oleoresin on cytogenic damage
in patients suffering from oral submucous fibrosis.