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Zinc and genistein together may help prevent age-related bone loss

  Several factors lead to the decrease of bone with aging; some of this decrease may be prevented by pharmacological and dietary intervention. A recent study demonstrated a direct stimulatory effect of genistein on bone formation in an in vitro tissue system. Genistein is a naturally occurring isoflavonoid phytoestrogen found in Fabaceae plants, such as soy and red clover. Zinc, an essential trace element, has also been shown to enhance bone formation and inhibit bone resorption, both in vitro and in vivo. The present study investigated the relationship between genistein and zinc and the effects of this combination on bone metabolism of elderly female rats. These researchers found that the isoflavonoid effect was enhanced by zinc; the combination may have a potent role in bone loss prevention.  
  Gao Y and Yamaguchi M., "Zinc enhancement of genisteinís anabolic effect on bone components in elderly female rats." Gen. Pharmac. 1998; 31(2):199-202.  
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