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Ginkgo: Greater improvement in peripheral arterial disease with higher dose

Numerous studies have shown that standardized Ginkgo biloba extract can help improve symptoms of peripheral arterial occlusive disease (PAOD), a circulatory disorder associated with narrowing of the arteries and consequent pain during walking. Based on the positive outcome of an earlier pilot trial, this clinical study was designed to compare the effects of two different dosages of ginkgo extract in order to confirm the therapeutic superiority of the higher dose. For the study, 38 people with PAOD took a standard dose of ginkgo extract (120 mg/day), while 36 were assigned to treatment with a dose twice as high as the standard (240 mg/day). After 24 weeks, both groups had "clinically relevant" improvements in pain-free walking distance, but the increase in pain-free walking distance was statistically significantly higher among those taking the higher dose. Both dosage regimens were reported to be safe and well tolerated. The standardized ginkgo extract used in the trial was EGb 761 (Rokan®), manufactured by W. Schwabe of Karlsruhe, Germany. Schweizer J, Hautmann C. Comparison of two dosages of Ginkgo biloba extract EGb 761 in patients with peripheral arterial occlusive disease Fontaine's stage IIb. Arzneim-Forsch/Drug Res 1999; 49(II): 900-904.

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